WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: gene_symbol, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=13; E=0.39; R=33.58; rawP=1.05e-16; adjP=2.21e-15
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  CXCL5 NA CXCL5 chemokine (C-X-C motif) ligand 5 6374 ENSG00000163735
2  CCL7 NA CCL7 chemokine (C-C motif) ligand 7 6354 ENSG00000108688
3  LIF NA LIF leukemia inhibitory factor 3976 ENSG00000128342
4  CSF3 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
5  CCL19 NA CCL19 chemokine (C-C motif) ligand 19 6363 ENSG00000172724
6  CCL20 NA CCL20 chemokine (C-C motif) ligand 20 6364 ENSG00000115009
7  IL8 NA IL8 interleukin 8 3576 ENSG00000169429
8  CXCL6 NA CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 6372 ENSG00000124875
9  CXCL1 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
10  IL10 NA IL10 interleukin 10 3586 ENSG00000136634
11  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
12  CCL18 NA CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 6362 ENSG00000006074
13  PPBP NA PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 5473 ENSG00000163736


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=9; E=0.28; R=32.60; rawP=9.50e-12; adjP=9.98e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  CXCL5 NA CXCL5 chemokine (C-X-C motif) ligand 5 6374 ENSG00000163735
2  CCL7 NA CCL7 chemokine (C-C motif) ligand 7 6354 ENSG00000108688
3  CCL19 NA CCL19 chemokine (C-C motif) ligand 19 6363 ENSG00000172724
4  CCL20 NA CCL20 chemokine (C-C motif) ligand 20 6364 ENSG00000115009
5  IL8 NA IL8 interleukin 8 3576 ENSG00000169429
6  CXCL6 NA CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 6372 ENSG00000124875
7  CXCL1 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
8  CCL18 NA CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 6362 ENSG00000006074
9  PPBP NA PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 5473 ENSG00000163736


Database:KEGG pathway       Name:Malaria       ID:05144
C=51; O=6; E=0.07; R=80.54; rawP=1.30e-10; adjP=9.10e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  CSF3 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
2  IL10 NA IL10 interleukin 10 3586 ENSG00000136634
3  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
4  CR1 NA CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1378 ENSG00000203710
5  SELE NA SELE selectin E 6401 ENSG00000007908
6  IL8 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:Rheumatoid arthritis       ID:05323
C=91; O=6; E=0.13; R=45.14; rawP=4.60e-09; adjP=2.42e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  CXCL1 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
2  CXCL5 NA CXCL5 chemokine (C-X-C motif) ligand 5 6374 ENSG00000163735
3  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
4  CCL20 NA CCL20 chemokine (C-C motif) ligand 20 6364 ENSG00000115009
5  IL8 NA IL8 interleukin 8 3576 ENSG00000169429
6  CXCL6 NA CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 6372 ENSG00000124875


Database:KEGG pathway       Name:Amoebiasis       ID:05146
C=106; O=4; E=0.15; R=25.83; rawP=1.84e-05; adjP=7.73e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  CXCL1 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
2  IL10 NA IL10 interleukin 10 3586 ENSG00000136634
3  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
4  IL8 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:Toxoplasmosis       ID:05145
C=132; O=4; E=0.19; R=20.74; rawP=4.34e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  IL10 NA IL10 interleukin 10 3586 ENSG00000136634
2  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
3  HSPA6 NA HSPA6 heat shock 70kDa protein 6 (HSP70B') 3310 ENSG00000173110
4  PLA2G2A NA PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 5320 ENSG00000188257


Database:KEGG pathway       Name:Leishmaniasis       ID:05140
C=72; O=3; E=0.11; R=28.52; rawP=0.0002; adjP=0.0006
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  IL10 NA IL10 interleukin 10 3586 ENSG00000136634
2  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
3  CR1 NA CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1378 ENSG00000203710


Database:KEGG pathway       Name:Chagas disease (American trypanosomiasis)       ID:05142
C=104; O=3; E=0.15; R=19.75; rawP=0.0005; adjP=0.0012
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  IL10 NA IL10 interleukin 10 3586 ENSG00000136634
2  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
3  IL8 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:Toll-like receptor signaling pathway       ID:04620
C=102; O=3; E=0.15; R=20.13; rawP=0.0005; adjP=0.0012
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  SPP1 NA SPP1 secreted phosphoprotein 1 6696 ENSG00000118785
2  LBP NA LBP lipopolysaccharide binding protein 3929 ENSG00000129988
3  IL8 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=4; E=0.39; R=10.22; rawP=0.0007; adjP=0.0015
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  TGFB2 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
2  GADD45G NA GADD45G growth arrest and DNA-damage-inducible, gamma 10912 ENSG00000130222
3  HSPA6 NA HSPA6 heat shock 70kDa protein 6 (HSP70B') 3310 ENSG00000173110
4  PLA2G2A NA PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 5320 ENSG00000188257




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).